Medical Reasons for Not Losing Weight: 2026 Guide
Explore medical reasons for not losing weight in our 2026 UK guide. Learn how hormones and medications impact your progress with evidence-based insights.
NEW
Foundayo®
Lose up to 13% of your body weight with Foundayo® (orforglipron).
*Based on clinical trials. Individual results may vary.
Coming soon
UK-Licensed Prescribers
All prescriptions reviewed by qualified UK prescribers
GPhC-Registered Pharmacy
Dispensed from a fully registered UK pharmacy
Discreet Next-Day Delivery
Plain packaging delivered to your door
Foundayo UK Prices
At XO, we believe in clarity and trust. Clear and transparent pricing so you always know what to expect.
Get Started in 3 Simple Steps
We’ve removed the hassle from healthcare. No waiting rooms, no awkward conversations. Just expert care, delivered.
Complete your consultation
Answer a few quick questions about your health and weight loss goals.
Get your prescription
A UK prescriber will review your answers and approve your treatment if suitable.
Receive your medication
Your Foundayo tablets are delivered discreetly to your door, with ongoing clinical support.
Frequently Asked Questions
What is Foundayo (Orforglipron)?
Foundayo is a once-daily oral tablet containing orforglipron, a GLP-1 receptor agonist. It is the world's first oral GLP-1 medication for weight loss, offering the same appetite-regulating mechanism as injectable options like Mounjaro and Wegovy — without the need for injections.
How does Foundayo compare to Mounjaro and Wegovy?
Mounjaro and Wegovy are weekly injections that typically produce greater weight loss (up to 22.5% and 15% respectively). Foundayo produces up to around 13% weight loss in clinical trials but has the significant advantage of being a simple once-daily tablet — ideal for those who prefer not to inject.
What is the price of Foundayo in the UK?
Foundayo prices start from £89 for the 3mg starting dose. Prices increase with higher maintenance doses, up to £169 for the 36mg maximum dose. All prices include prescription review, clinical support, and discreet delivery.
Does Foundayo need to be refrigerated?
No. Unlike injectable GLP-1 medications which require refrigeration, Foundayo tablets can be stored at room temperature. This makes them ideal for travel and everyday convenience.
Who is Foundayo suitable for?
Foundayo may be suitable for adults with a BMI of 30 or above, or 27 and above with a weight-related health condition. It's particularly suited to those who want the benefits of GLP-1 treatment without injections. Our prescribers assess your suitability during the online consultation.
Are there side effects with Foundayo?
As with all GLP-1 medications, the most common side effects include nausea, vomiting, diarrhoea, and constipation — particularly when starting treatment. These typically improve over time. Our clinical team will guide you through managing any side effects throughout your treatment.
Expert Care
Your dedicated medical team.
World-class UK healthcare professionals. Prescribing the most effective treatments, combined with your personalised plan, to deliver life-changing results.
Roger Compton
Independent Prescriber
Finalist 'Independent Prescriber of the Year'
Independent Pharmacy Awards, House of Commons
- GPhC: 2082993
- Over 10 years clinical pharmacy experience
- Special interest in weight management & metabolic health
"We are here to upgrade the way people achieve better health — safely, simply, and effectively."
Alice Kwissa
Dietitian
- HCPC: DT032637
- Weight Management & Metabolic Health
- Nutrition & lifestyle support
"Food should make you feel good. I'll help you build healthy habits that actually fit your busy life."
Phoebe Jackson
Pharmacist
- GPhC: 2224320
- Dispensing & patient safety
- Clinical Pharmacy
"It's completely normal to feel overwhelmed at the start. I'm here to make sure you feel supported every step of the way."
Naomi Nsiah
Mental Health Nurse
- NMC Registered
- Specialist Mental Health Support
- Holistic Patient Care
"Your mental wellbeing is just as important as the physical changes. We'll navigate this journey together."
Imran Hafiji
Pharmacist
- GPhC: 2063130
- Dispensing & patient safety
- Clinical Pharmacy
"There's no one-size-fits-all approach. I'm dedicated to finding what genuinely works for your body and your lifestyle."
Kimia Nasriavarzman
Pharmacist
- GPC: 2227364
- Dispensing & patient safety
- Clinical Pharmacy
"Taking that first step is always the hardest part. My goal is to make everything else straightforward and safe."
Why 30k members trust XO
UK Prescribers
Your treatment is managed by experienced prescribers who ensure safe and effective recommendations for Foundayo weight loss tablets and other licensed medical options tailored to your needs.
GPhC Registered Pharmacy
All medications, including Foundayo tablets, are dispensed through a GPhC-registered online pharmacy — giving you complete confidence in the authenticity, safety, and reliability of your prescription.
Unlimited 1:1 Support
Receive unlimited one-to-one guidance from qualified healthcare professionals who support every step of your Foundayo weight loss journey — from dosage adjustments to ongoing lifestyle advice.
Class-Leading App
Monitor your progress, access expert tips, and stay connected with our clinical team through a class-leading mobile app that makes your daily Foundayo tablet simple, structured, and sustainable.
Ready to begin?
Full ongoing support, including nutritional guidance, lifestyle coaching, and access to our free app.
Foundayo Insights
Expert advice from our medical team.
