Will Walking Tone My Legs? An Evidence-Based Guide
Will walking tone my legs? Discover the evidence-based answer. Learn how walking affects leg muscles, factors that influence results, and how to get started.
In clinical trials
Retatrutide
Lose up to 29% of your body weight with Retatrutide (retatrutide).
*Based on clinical trials. Individual results may vary.
UK-Licensed Prescribers
All prescriptions reviewed by qualified UK prescribers
GPhC-Registered Pharmacy
Dispensed from a fully registered UK pharmacy
Discreet Next-Day Delivery
Plain packaging delivered to your door
Currently in clinical trials
Not yet commercially available
Retatrutide is currently in Phase 3 clinical trials and has not yet received regulatory approval for commercial prescribing in the UK. Register your interest now and our team will reach out as soon as it becomes available.
No commitment required. We'll notify you when this treatment is available.
How to Register Your Interest
Register your interest
Complete a brief form telling us about your health and weight loss goals.
Clinical assessment
Our prescribing team will review your suitability for the Retatrutide programme.
Early access notification
You'll be contacted as soon as Retatrutide becomes available through our clinic.
Frequently Asked Questions
What is Retatrutide?
Retatrutide is a once-weekly injectable weight loss medication that activates three hormone receptors simultaneously — GLP-1, GIP, and glucagon. This triple-action mechanism makes it significantly more potent than existing GLP-1 or dual-agonist treatments, with clinical trials showing up to 29% body weight loss.
How does Retatrutide compare to Mounjaro?
Mounjaro (tirzepatide) is a dual agonist targeting GLP-1 and GIP, producing up to 22.5% weight loss. Retatrutide adds glucagon receptor activation on top of this — creating a triple-action effect that achieves up to 29% weight loss in clinical trials, making it the most potent injectable weight loss treatment studied to date.
When will Retatrutide be available in the UK?
Retatrutide is currently in Phase 3 clinical trials and has not yet received regulatory approval for commercial prescribing in the UK. Regulatory review is expected in the coming years. Register your interest with us and we'll notify you as soon as it becomes available through our pharmacy.
How do I inject Retatrutide?
Retatrutide comes as a pre-filled pen that you inject once weekly under the skin of your stomach, thigh, or upper arm. The needle is very fine and most people find it comfortable. We provide full video guidance and clinical support to help you feel confident from day one.
Who is Retatrutide suitable for?
Retatrutide may be suitable for adults with a BMI of 30 or above, or 27 and above with weight-related health conditions. It may be particularly appropriate for those who have not achieved their goals with other GLP-1 medications. Our prescribers assess your full medical history during the online consultation.
Are there side effects with Retatrutide?
As with all GLP-1 based medications, the most common side effects include nausea, vomiting, diarrhoea, and constipation — particularly during dose titration. These typically improve as your body adjusts. Our clinical team will support you through any side effects throughout your treatment.
Expert Care
Your dedicated medical team.
World-class UK healthcare professionals. Prescribing the most effective treatments, combined with your personalised plan, to deliver life-changing results.
Roger Compton
Independent Prescriber
Finalist 'Independent Prescriber of the Year'
Independent Pharmacy Awards, House of Commons
- GPhC: 2082993
- Over 10 years clinical pharmacy experience
- Special interest in weight management & metabolic health
"We are here to upgrade the way people achieve better health — safely, simply, and effectively."
Alice Kwissa
Dietitian
- HCPC: DT032637
- Weight Management & Metabolic Health
- Nutrition & lifestyle support
"Food should make you feel good. I'll help you build healthy habits that actually fit your busy life."
Phoebe Jackson
Pharmacist
- GPhC: 2224320
- Dispensing & patient safety
- Clinical Pharmacy
"It's completely normal to feel overwhelmed at the start. I'm here to make sure you feel supported every step of the way."
Naomi Nsiah
Mental Health Nurse
- NMC Registered
- Specialist Mental Health Support
- Holistic Patient Care
"Your mental wellbeing is just as important as the physical changes. We'll navigate this journey together."
Imran Hafiji
Pharmacist
- GPhC: 2063130
- Dispensing & patient safety
- Clinical Pharmacy
"There's no one-size-fits-all approach. I'm dedicated to finding what genuinely works for your body and your lifestyle."
Kimia Nasriavarzman
Pharmacist
- GPC: 2227364
- Dispensing & patient safety
- Clinical Pharmacy
"Taking that first step is always the hardest part. My goal is to make everything else straightforward and safe."
Why 30k members trust XO
UK Prescribers
Your treatment is managed by experienced prescribers who ensure safe and effective recommendations for Retatrutide weight loss injections and other licensed medical options tailored to your needs.
GPhC Registered Pharmacy
All medications, including Retatrutide injections, are dispensed through a GPhC-registered online pharmacy — giving you complete confidence in the authenticity, safety, and reliability of your prescription.
Unlimited 1:1 Support
Receive unlimited one-to-one guidance from qualified healthcare professionals who support every step of your Retatrutide weight loss plan — from dosage adjustments to ongoing lifestyle advice.
Class-Leading App
Monitor your progress, access expert tips, and stay connected with our clinical team through a class-leading mobile app that makes injecting Retatrutide simple, structured, and sustainable.
Be first in line
Register your interest today. When Retatrutide becomes commercially available, our team will reach out to you directly — no commitment required.
Retatrutide Insights
Expert advice from our medical team.
